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Publications

(* denotes corresponding author; § denotes equal contribution)

 

17. Jian, B-S; Chiou, S-L; Hsu, C-C; Ho, Josh; Wu, Y-W; Chu, J*. Bioinformatic analysis reveals both oversampled and underexplored biosynthetic diversity in nonribosomal peptides. ACS Chem. Biol. 2023, 18, 476 (doi: 10.1021/acschembio.2c00761).

 

16. Chen, I-H; Cheng, T; Wang, Y-L; Huang, S-J; Hsiao, Y-H; Lai, Y-T; Tor, S-I; Chu, J; Rudolf, JD; Chang, C-Y. Characterization and structural determination of CmnG-A, the adenylation domain that activates the nonproteinogenic amino acid capreomycidine in capreomycin biosynthesis. ChemBioChem 2022, e202200563 (doi: 10.1002/cbic.202200563).

15. §Chen, P-H; §Sung, L-K; Hegemann, JD; Chu, J*. Disrupting transcription and folate biosynthesis leads to synergistic suppression of Escherichia coli growth. ChemMedChem 2022, e202200075 (doi: 10.1002/cmdc.202200075).

14. Wu, C-H; Chu, J*. Total synthesis and antimicrobial evaluation of pagoamide A. Front. Chem. 2021, 9:741290 (doi: 10.3389/fchem.2021.741290).

13. Chung, H-H; Kao, C-Y; Wang, A T-S; Chu, J; Pei, J; Hsu, C-C. Reaction tracking and high-throughput screening of active compounds in combinatorial chemistry by tandem mass spectrometry molecular networking. Anal. Chem. 2021, 93, 2456-2463 (doi: 10.1021/acs.analchem.0c04481).

======== NTU publications ========

12. Chu, J; Koirala, B; Forelli, N; Vila-Farres, X; Ternei, MA; Ali, T; Colosimo, DA; Brady, SF. Synthetic-bioinformatic natural product antibiotics with diverse modes of action. J. Am. Chem. Soc. 2020, 142, 14158-14168 (doi: 10.1021/jacs.0c04376). 

11. Chu, J; Vila-Farres, X; Brady, SF. Bioactive synthetic-bioinformatic natural product cyclic peptides inspired by nonribosomal peptide synthetase gene clusters from the human microbiome. J. Am. Chem. Soc. 2019, 141, 15737-15741 (doi: 10.1021/jacs.9b07317). 

10. §Vila-Farres, X; §Chu, J; Ternei, MA; Lemetre, C; Park, S; Perlin, DS; Brady, SF. An optimized synthetic-bioinformatic natural product antibiotic sterilizes multidrug-resistant Acinetobacter baumannii-infected wounds. mSphere 2018, 3, e00528-17 (doi: 10.1128/mSphere.00528-17). 

9. §Chu, J; §Vila-Farres, X; Inoyama, D; Gallardo-Macias, R; Jaskowski, M; Satish, S; Freudlich, JS; Brady, SF. Human microbiome inspired antibiotics with improved β-lactam synergy against MDR Staphylococcus aureus. ACS Infect. Dis. 2018, 4, 33-38 (doi: 10.1021/acsinfecdis.7b00056). 

  • Featured as the Cover Story in the <<Human Microbiome>> Special Issue of ACS Infectious Diseases, (January 2018).

 

8. Cohen, LJ; Esterhazy, D; Kim, SH; Lemetre, C; Aguilar, RR; Gordon, EA; Pickard, AJ; Cross, JR; Emiliano, AB; Han, SM; Chu, J; Vila-Farres, X; Kaplitt, J; Rogoz, A; Calle, P; Hunter, C; Bitok, JK; Brady, SF. Commensal bacteria make GPCR ligands that mimic human signaling molecules. Nature 2017, 549, 48-53 (doi: 10.1038/nature23874).

  • Reported by Technology Networks, The Medical News, Phys.Org, etc.

7. §Vila-Farres, X; §Chu, J; Inoyama, D; Ternei, MA; Lemetre, C; Cohen, LJ; Cho, W; Reddy, BVB; Zebroski, HA; Freudlich, JS; Perlin, DS; Brady, SF. Antimicrobials inspired by nonribosomal peptide synthetase gene clusters. J. Am. Chem. Soc. 2017, 139, 1404-1407 (doi: 10.1021/jacs.6b11861).

  • Reported by Nature Reviews Chemistry (2017, 1, 22) and Faculty 1000 Prime

6. §Chu, J; §Vila-Farres, X; Inoyama, D; Ternei, MA; Cohen, LJ; Gordon, EA; Reddy, BVB; Charlop-Powers, Z; Zebroski, HA; Gallardo-Macias, R; Jaskowski, M; Satish, S; Park S; Perlin, DS; Freudlich, JS; Brady, SF. Discovery of MRSA active antibiotics using primary sequence from the human microbiome. Nat. Chem. Biol. 2016, 12, 1004-1006 (doi: 10.1038/nchembio.2207). 

  • Reported by Science Daily, SciNews, Nature World NewsArs Technica and highlighted by Faculty 1000 Prime

 

5. Cohen, LJ; Kang, HS, Chu, J; Huang, YH; Gordon, EA; Reddy, BV; Ternei, MA; Craig, JW; Brady, SF. Functional metagenomic discovery of bacterial effectors in the human microbiome and isolation of commendamide, a GPCR G2A/132. Proc. Natl. Acad. Sci. 2015, 112, E48245 (doi: 10.1073/pnas.1508737112).

  • Highlighted by Faculty 1000 Prime

4. Melicher, MS; Chu, J; Walker, AS; Miller, SJ; Baxter, RHG; Schepartz, A. A β-boronopeptide bundle of known structure for differential polyol recognition. Org. Lett. 2013, 15, 5048-5051 (doi: 10.1021/ol402381n).

3. Chu, J; González-López, M; Cockroft, SL; Amorin, M; Ghadiri, MR. Real-time monitoring of DNA polymerase function and stepwise single-nucleotide DNA strand translocation through a protein nanopore. Angew. Chem. Int. Ed. 2010, 49, 10106-10109 (doi: 10.1002/anie.201005460).

  • Reported by RSC Chemistry World and Nano Today

2. Cockroft, SL; Chu, J; Amorin, M; Ghadiri, MR. A single-molecule nanopore device detects DNA polymerase activity with single-nucleotide resolution. J. Am. Chem. Soc. 2008, 130, 818-820 (doi: 10.1021/ja077082c).

  • Reported by Nat. Nanotech. (2008, 3, 126), and ACS Chem. Biol. (2008, 3, 92).

1. Huang, KF; Ko, TP; Hung, CC; Chu, J; Wang, AHJ; Chiou, SH. Crystal structure of a platelet-agglutinating factor isolated from the venom of Taiwan habu (Trimeresurus mucrosquamatus). Biochem. J. 2004, 378, 399-407 (doi: 10.1042/bj20031507).

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